Oliver D. King, Ph.D.

Scientist
Computational biology, evolutionary dynamics, protein misfolding, neurodegenerative diseases, muscular dystrophies
king@bbri.org

 

Research Summary

My research involves using computational and mathematical approaches to illuminate biological systems. Current projects include modeling the evolution of proteins involved in neurodegenerative disorders, and analyzing high-throughput experimental data to understand how genetics and environmental factors interact to influence phenotype

 

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Selected Publications

 

  • Steele, A. D., Hutter, G., Jackson, W. S., Heppner, F. L., Borkowski, A. W., King, O. D., Raymond, G. J., Aguzzi, A. & Lindquist, S. (2008). Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. [Epub ahead of print]
  • Tian, W., Zhang, L. V., Tasan, M., Gibbons, F. D., King, O. D., Park, J., Wunderlich, Z., Cherry, J. M. & Roth, F. P. (2008). Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1, S7. [Epub ahead of print]
  • King, O. D. & Masel, J. (2007). The evolution of bet-hedging adaptations to rare scenarios. Theor Popul Biol, in press.
  • Steele, A. D., Jackson, W. S., King, O. D. & Lindquist, S. (2007). The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A 104, 1983-8.
  • King, O. D. & Gaborit, P. (2007). Binary templates for comma-free DNA codes. Discrete Applied Mathematics 155, 831-839.
  • Zhang, L. V., King, O. D., Wong, S. L., Goldberg, D. S., Tong, A. H., Lesage, G., Andrews, B., Bussey, H., Boone, C. & Roth, F. P. (2005). Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol 4, 6.
  • King, O. D., Foulger, R. E., Dwight, S. S., White, J. V. & Roth, F. P. (2003). Predicting gene function from patterns of annotation. Genome Res 13, 896-904.
  • King, O. D. & Roth, F. P. (2003). A non-parametric model for transcription factor binding sites. Nucleic Acids Res 31, e116.

 

PubMed:
Click here for a list of publications (searches the National Library of Medicine's PubMed database.)

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